Lutes

I was looking up Hungarian composers, and got distracted by Bakfark "While Bakfark almost certainly wrote an enormous amount of music, very little was printed: a commonly given reason was that it was simply too difficult for others to play." and "As was common practice at the time, all the possessions of plague victims were destroyed by fire, so most of his manuscript music was lost."

Plagues cause irretrievable losses.

I leave it to lutists to say how complicated the surviving works are.